Lab Info
Name:
CTTB Biobank and Registry for Atopic dermatitis
Principal investigator:
Dr. Carolyn Jack
Location:
Montreal, Quebec
Contact:
Gaurav Isola
gaurav.isola@mail.mcgill.ca
Objective/description
The Transdisciplinary Centre for Biological Therapies (Centre Transdisciplinaire de Thérapies Biologiques or CTTB) is a multidisciplinary, integrated approach for patients who are receiving therapies directed at the immune system. The CTTB Biobank and Registry for Atopic dermatitis has been created to collect and store blood, skin tissue and other types of biological samples, as well as clinical information, for current and future research purposes.
Objectives:
To identify the impact of various treatments for dermatitis on patient symptoms, quality of life and disease outcome.
To characterize (including potential sequencing) skin lesions and matched normal tissues at the molecular and cellular level (the cells, the DNA, RNA and proteins, as well as their regulatory factors), to help better understand disease biology, prognosis and response to therapy, with a potential to identify new targets for improved treatments.
To characterize cells, proteins and genetic material (RNA and DNA) in the blood or other bodily fluids to identify characteristics that may act to identify specific kinds of skin diseases, or to predict response to therapy or disease outcome.
To characterize biomarkers, including those related to microbiome (bacteria that live on or in humans) to identify potential disease markers, markers of response to therapy or prognostic markers.
Collection Details
Skin conditions represented:
- Atopic dermatitis
- Normal skin
Anatomic sites:
- Skin area with active lesion (antecubital fossa, popliteal fossa, flexural neck etc.)
- Peri lesional skin area (around the lesional area)
- Non-lesional skin area matching the corresponding lesional area
Specimen types:
- Tissue:
- Cell & cell lines:
- Blood & blood derivatives:
- Fluid derivatives (plasma, serum)
- Cellular derivatives – Peripheral blood mononuclear cells
- Other derivatives
- Swabs
- Traditional Microbiology
- Genomic Analysis
Dr. Philippe Lefrancois, Assistant Professor, Division of Experimental Medicine, McGill University.
Dr. David Croitoru, Clinical Associate, Division of Dermatology, University of Toronto.
Dr. Amani Hassan, Postdoctoral Fellow, Department of Surgery, McGill University.
