SkIN Canada Skin Investigation Network of Canada

Newsletter

Funded by

Institute of Musculoskeletal Health and Arthritis

IN THIS ISSUE

Research Map

Directory of Canadian skin researchers

Subscribe to Newsletter

Featured profiles

Kathleen Barnard is the founder of Save Your Skin Foundation. Kathy prioritizes patient care and support. She was a key player in federal tanning bed legislation for Canada’s Youth and she continues this area of focus on education and awareness, providing emotional and financial support to those dealing with melanoma and carcinoma skin cancers, prevention, access, and support of the ongoing research and treatment of skin cancer – from melanoma to actinic keratosis. As both a melanoma and immunotherapy survivor, Kathleen and her Foundation hope to share the experience and knowledge gained, by leading other patient groups in knowledge and advocacy training to ensure equal timely access to new treatments for all cancer patients……

READ FULL INTERVIEW

 

 

Spring 2023

Featured profile: Mid-Career Investigator

Sarah Hedtrich, Ph.D.

Associate Professor, faculty of Pharmaceutical Sciences, Vancouver Campus

Fields:

NanotechnologyPharmaceuticalsPharmaceuticals / Drugs

Expertise:

pharmacology, biomedical engineering, drug delivery, next-generation therapies, nanomedicine, tissue engineering, skin

After finishing her studies of Pharmaceutical Sciences at the University of Leipzig, Germany, Dr. Hedtrich completed her Ph.D. in pharmacology & toxicology at the Freie Universität Berlin. During her postdoc, she moved to the Ludwig-Maximilians-University in Munich and the Tufts University in Boston, USA. After returning to Berlin, she headed a junior research group from 2013-2015 before she was appointed as an assistant professor in April 2015. Since January 2019, she is an associate professor with a tenure track at the University of British Columbia, Canada. Her lab combines research expertise in pharmacology, biomedical engineering & drug delivery. They focus on the establishment of Next Generation Therapies, Nanomedicine, Tissue Engineering & Tissue Regeneration. They are particularly interested in healthy and diseased states of human epithelia with a current focus on inflammatory and genetic diseases of the human skin and lungs. Their research is highly interdisciplinary and requires close collaborations with experts in the field of chemistry, medicine and genetics.

Who has influenced your choice of research the most? And why?

 

My interest in skin started with the topic of my PhD thesis which dealt with characterizing and developing novel nanoparticulate carrier systems to facilitate topical drug delivery. I had the opportunity to attend several international meetings where I met other interdisciplinary skin researchers that worked on the basic, translational and clinical side of things. Somehow, I got fascinated by the skin and stuck to it. So, if you are asking ‘Who’ it would be probably my PhD supervisor who suggested the topic to me. The skin research I am currently doing, however, evolved over time and is a melting pot of interdisciplinary elements which I picked up at the different academic stages and institutions over the past years.


What are the greatest challenges you have faced or are facing in your research area?

 

As a non-clinician, it is always challenging to get access to patient material, which, however, is often pivotal for our research. To overcome this drawback, I maintain close collaborations with clinicians who facilitate patient recruitment or take biopsies and such. While this works generally well, it is sometimes difficult to establish such connections and to find clinicians who are willing to carve out time from their clinical work to support bench science. Other than that, my research is highly collaborative and interdisciplinary which is great as such, but logistics and project management can be challenging at times as many different players need to be coordinated.


What can be done to grow the impact of skin research in Canada?

 

I think fostering better connections and networks between established and junior people engaged or interested in skin research (basic, translational and clinician scientists and patient groups) is key. This is exactly SKiN Canada’s mandate, and therefore this initiative is so important. In addition to that, the limited funding options in Canada are problematic but this is skin unspecific.


If you have worked with patients as part of the research team, what did you learn? if you have not yet, what are you looking forward to learning from patient research partners?

 

I am always impressed by how well-informed and up-to-date patients are regarding medications, novel treatment options and such. It was also super helpful to better understand their needs, their point of view, and their pain points. Also, most of the patients are super supportive of research activities even when it’s not directly benefiting them. This is very impressive. Finally, patients and their stories really motivate me as helping them is basically why I am doing what I am doing.


What are the key factors that attract trainees and early career investigators to choose skin research as their field of study?

 

Initially, I think it’s often by chance unless there is an intrinsic interest, maybe triggered by their very own skin disease or an affected family member. Another avenue is engaging in outreach activities to get attention for the work we do. Or offering and advertising internships for undergraduate students which I found to be a quite fruitful approach.

Once in the system, community building is super important which provides the trainees and ECRs with the opportunity to connect, build collaborations, and discuss challenges, but also to meet more senior people that could be the potential next step when building their career.

From the SkIN Canada Patient Engagement Hub

What is the difference between focus (discussion) groups as patient engagement versus focus groups as qualitative research?

Patient engagement is an opportunity for people with experience of a health-related issue to contribute to research on that issue. The Canadian Strategy for Patient-Oriented Research (SPOR) highlights patient engagement as an important part of health research. Patient engagement, however, is a new concept for many researchers and research ethics boards, and it can be difficult to understand the differences between patient engagement activities and research activities. Focus groups are one example of how research and patient engagement activities are often confused.

We distinguish these two types of activities by using different terms for each. We use focus groups to refer to research activities, and discussion groups to refer to patient engagement activities. In focus groups, researchers collect data by speaking with a group of research subjects about their experiences. Researchers use this information to answer research questions and share their findings in academic journals and gatherings. In patient engagement, discussion groups are a way for patients to help plan research projects. Their contributions are not treated as research data, but instead, they help make decisions that shape the research process. We have found that using different languages to refer to each type of activity has led to improved clarity in research planning and research ethics submissions. This information is in reference to the work done by the Maritime Strategy for Patient-Oriented Research  (SPOR) Unit.

FIND OUT MORE ABOUT MARITIME SPOR (CLICK HERE)

From the SkIN Canada Training Hub
1. The next SkIN Canada Training Committee Meeting is scheduled for Thursday April 20th at 2:00 PM ET.

2. The Skin Canada 2023 Quarterly Webinar will be held on Wednesday June 7th at 3:00 PM ET. The Webinar will feature Dr. David Croituro from the University of Toronto and Dr. Philippe Lefrancois from McGill University. The Webinar will focus on “Novel Technologies to Study Skin Biology and Skin Diseases.”

3. SkIN Canada is now accepting applications for Trainee Travel Awards. The deadline for receiving the application is Monday, May 15th at 11:59 PM ET. 
4. SkIN Canada is also now accepting applications for Trainee Mobility Awards. The deadline for receiving the application is Monday, May 15th at 11:59 PM ET. 
News from other organizations

Clinical Trials Ontario (CTO): Call for Members of the College of Lived Experience

Clinical Trials Ontario (CTO) is an independent not-for-profit organization established with support from the Government of Ontario. Our mandate is to work together with the clinical trials community, the public, and other partners to improve Ontario’s clinical trials environment. Since 2012 we have been carrying out our mandate with one of our three strategic pillars being patient and public engagement. We believe engaging patients and the public is critical to improving the environment for clinical trials in Ontario and will result in better clinical trials, better experiences for trial participants, better physician-researcher experiences, and in the long run, a better health care system. More information about Clinical Trials Ontario can be found at www.ctontario.ca.

Apply to become a CIHR Institute Advisory Board Member

The CIHR Institute of Musculoskeletal Health and Arthritis is seeking new members to serve on its Institute Advisory Board (IAB). SkIN Canada’s Managing Director, Professor An-Wen Chan, currently serves as Vice-Chair and incoming Chair of the IAB and would be happy to answer any questions.

Apply here

Email info@skincanada.org with questions

Understanding pain in scleroderma: A patient-researcher partnership

In this episode of Arthritis At Home, Ellen Wang, Programs Coordinator, Arthritis Consumer Experts, speaks to Dr. Brett Thombs, Professor, Faculty of Medicine, McGill University, and Director, Scleroderma Patient-centered Intervention Network (SPIN). Recently, his team was obtained an Ignite Grant from the Arthritis Society for the project titled “A Scleroderma Patient-centered Intervention Network patient-researcher partnership to understand pain sources, patterns, and barriers to effective management in systemic sclerosis.”

They discuss the importance of integrating the patient voice at all stages of research and the benefits of doing so. Dr. Thombs explains that patients have the choice of how they want to be involved and no formal experience is needed.

Additional learning resources

WATCH VIDEO

Recent Publications by SkIN Canada Members

Inflammatory Skin Conditions

  1. Quaglino P, Scarisbrick J, Roccuzzo G, Abeldano A, Battistella M, McCormack C, Cowan R, Cozzio A, Cury-Martins J, Enz P et al: Identifying unmet needs and challenges in the definition of a plaque in mycosis fungoides: An EORTC-CLTG/ISCL survey. J Eur Acad Dermatol Venereol 2023, 37(4):680-688.
  2. Gupta AK, Wang T, Polla Ravi S, Bamimore MA, Piguet V, Tosti A: Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase-4 inhibitors. J Eur Acad Dermatol Venereol 2023, 37(4):666-679.
  3. Eichenfield LF, Stein Gold L, Kircik LH, Werschler WP, Beer K, Draelos ZD, Tanghetti EA, Papp KA, Baldwin H, Lain E et al: Triple-combination clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel for moderate-to-severe acne in children and adolescents: Randomized phase 2 study. Pediatr Dermatol 2023.
  4. Blauvelt A, Thaçi D, Papp KA, Ho V, Ghoreschi K, Kim BS, Miller M, Shen YK, You Y, Chan D et al: Safety of guselkumab in patients with psoriasis with a history of malignancy: 5-year results from the VOYAGE 1 and VOYAGE 2 trials. The British journal of dermatology 2023.
  5. Croitoru DO, Piguet V: T Cells Remember SARS-CoV-2 in Rituximab-Treated Pemphigus Vulgaris. The Journal of investigative dermatology 2023.

Read More

Wound Healing, Fibrosis and Regeneration

  1. Sibbald RG, Ayello E: Results of the 2022 Wound Survey on Skin Failure/End-of-Life Terminology and Pressure Injuries. Adv Skin Wound Care 2023, 36(3):151-157.
  2. Brady EL, Prado O, Johansson F, Mitchell SN, Martinson AM, Karbassi E, Reinecke H, Murry CE, Davis J, Stevens KR: Engineered tissue vascularization and engraftment depends on host model. Scientific reports 2023, 13(1):1973.
  3. Naasani LIS, Sévigny J, Moulin VJ, Wink MR: UTP increases wound healing in the self assembled skin substitute (SASS). J Cell Commun Signal 2023.

Read More

Skin Cancer

  1. van Bodegraven B, Vernon S, Eversfield C, Board R, Craig P, Gran S, Harwood CA, Keohane S, Levell NJ, Matin RN et al“Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in EnglandThe British journal of dermatology 2023.
  2. Nguyen A, Xie P, Litvinov IV, Lefrançois P: Efficacy and Safety of Sonic Hedgehog Inhibitors in Basal Cell Carcinomas: An Updated Systematic Review and Meta-analysis (2009-2022)Am J Clin Dermatol 2023.
  3. Mirali S, Tang E, Drucker AM, Turchin I, Gooderham M, Levell N, Beecker J, Bissonnette R, Catherall H, Lapointe McKenzie JA et alFollow-up of Patients With Keratinocyte Carcinoma: A Systematic Review of Clinical Practice GuidelinesJAMA Dermatol 2023, 159(1):87-94.
  4. Jicman PA, Smart H, Ayello EA, Sibbald RG: Early Malignant Melanoma Detection, Especially in Persons with Pigmented SkinAdv Skin Wound Care 2023, 36(2):69-77.
  5. Devasenapathy N, Chu A, Wong M, Srivastava A, Ceccacci R, Lin C, MacDonald M, Wen A, Steen J, Levine M et alCancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysisLancet Child Adolesc Health 2023, 7(1):13-25.

Read More

Other

  1. Weng J, Zhou LL, Hahn T, Shojania K, Dutz J: Adult-Onset Still Disease After ChAdOx1 nCOV-19 VaccinationJ Rheumatol 2023, 50(2):290-291.
  2. Sibbald RG, Hastings-Truelove A, DeJong P, Ayello EA: Reconciliation and Diversity for Educators: The Medicine Wheel, Bloom’s Taxonomy, and CanMEDS CompetenciesAdv Skin Wound Care 2023, 36(2):64-66.
  3. Shah SD, Mathes EF, Baselga E, Frieden IJ, Powell J, Garzon MC, Morel KD, Lauren CT, Mancini AJ, Chamlin SL et alMulticenter retrospective review of pulsed dye laser in nonulcerated infantile hemangiomaPediatr Dermatol 2023, 40(1):28-34.
  4. Schachner L, Alexis A, Andriessen A, Baldwin H, Cork M, Kirsner R, Woolery-Lloyd H: Supplement Individual Article: The Importance of a Healthy Skin Barrier From the Cradle to the Grave Using Ceramide-Containing Cleansers and Moisturizers: A Review and ConsensusJ Drugs Dermatol 2023, 22(2):SF344607s344603-SF344607s344614.
  5. Nejstgaard CH, Boutron I, Chan AW, Chow R, Hopewell S, Masalkhi M, Moher D, Schulz KF, Shlobin NA, Østengaard L et alA scoping review identifies multiple comments suggesting modifications to SPIRIT 2013 and CONSORT 2010J Clin Epidemiol 2023, 155:48-63.

Read More

SkIN Canada Executive Committee