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To help establish a framework for coordinating multi-centre skin studies involving community and academic research sites, the clinical trials arm of SkIN Canada initiated two small-scale non-interventional research projects.
First Edition | February 2022
SkIN Canada Supported projects
Purpose of the SkIN Canada Demo Projects:
SkIN Canada is developing data infrastructure and resources to facilitate multicentre research. To demonstrate proof-of-principle, SkIN Canada sought to initially partner with research projects that were early in their development phase. In November 2020, the network issued a request for proposals and selected two multicentre projects that had already secured funding and were in need of data infrastructure. SkIN Canada’s partnership in these projects has informed the development of core data infrastructure and services based on a REDCap platform.
Canadian Atopic dermatitis Cohort for Translational Immunology and imaging (CACTI):
Atopic Dermatitis (Eczema) is clinically treated as a single entity, but atopic dermatitis may be the final skin-based presentation of a varied group of conditions. There are a multitude of distinct physiological causes including skin barrier defects, environmental and microbial triggers and dysregulated immune response that can contribute to the development of atopic dermatitis. Several different treatment strategies are used to address these varied causes with variable success.
CACTI’s objective is to resolve knowledge gaps by creating a cohort of adult atopic dermatitis patients that do not respond to topical therapy. Funded by the Canadian Dermatology Foundation, this cohort will be leveraged to establish subtypes of the condition that can aid in individualizing treatment, test advanced imaging techniques to measure the condition, and establish guidelines for using phototherapy to treat eczema.
SkIN Canada helped develop a centralized database to coordinate and record data and tissue sample collection from multiple study sites.
The investigators are:
Dr. Aaron Drucker, MD, FRCPC; Women’s College Hospital, University of Toronto (Lead investigator)
Dr. Carolyn Jack, MD, FRCPC, McGill University Health Centre
Dr. Sunil Kalia, MD, FRCPC, University of British Colombia
Dr. Vincent Piguet, MD, FRCPC, Women’s College Hospital, University of Toronto
Canadian Morphea Registry (C-MoRe):
While localized scleroderma (morphea) has significant impact on patients’ quality of life, the molecular cause of the condition is not well understood. As such, there are no targeted therapies for morphea, and the only current management strategy is to try to slow down the condition’s progression with immunosuppressants.
The aim of this project is to develop a national morphea registry that will collect longitudinal clinical and laboratory data and tissue samples. The creation of this registry will enable skin researchers to study the causes and risk factors of morphea, the burden of disease and identify biomarkers that can aid in treatment. C-MoRe is working in collaboration with patients’ partners (Canadian Skin Patients Alliance) and is comprised of a multidisciplinary team of investigators with expertise in pediatric and adult dermatology and rheumatology.
SkIN Canada is creating an online data capture platform that will enable data and tissue collection by investigators from across Canada.
These investigators include:
Dr. Elena Netchiporouk, McGill University (Lead investigator)
Dr. Elizabeth O’Brien, McGill University
Dr. Gaelle Chédeville, McGill University
Dr. Kevin Pehr, McGill University
Dr. Catherine McCuaig, Université de Montréal
Dr. Mariam Pyram, Université de Montréal
Dr. Jean-Philippe Proulx-Gauthier, Université Laval
Dr. Marie-Claude Dionne, Université Laval
Dr. Alexandra Bruns, Université de Sherbrooke
Dr. Lyne Bissonnette, Université de Sherbrooke
Dr. Mylène Veilleux, Université de Sherbrooke
Dr. Elena Pope, University of Toronto
Dr. Ronald Laxer, University of Toronto
Dr. Cathryn Sibbald, University of Toronto
Dr. Yuka Asai, Queen’s University
Dr. Johannes Roth, University of Ottawa
Dr. Roberta Berard, Western University
Dr. Michelle Batthish, McMaster University
Dr. Robert Gniadecki, University of Alberta
Dr. Dax Rumsey, University of Alberta
Dr. Nadia Luca, University of Calgary
Dr. Heinrike Schmeling, University of Calgary
Dr. Vimal Prajapati, University of Calgary
Dr. David Cabral, University of British Columbia
Dr. Kristin Houghton, University of British Columbia
Dr. Andrea Human, University of British Columbia
Dr. Jan Dutz, University of British Columbia
Dr. Paul Dancey, Memorial University
Dr. Irina Turchin, Dalhousie University
Dr. Adam Huber, Dalhousie University
Dr. Mehul Jariwala, University of Saskatchewan
Rachael Manion is the Executive Director of the Canadian Skin Patient Alliance and the Canadian Association of Psoriasis Patients. She is also Chair of the Patient Advisory Council of the Skin Investigation Network of Canada (SkIN Canada) and a member of the Executive Committee. Drawing on her background as a lawyer and consultant, Rachael brings a strategic and creative approach to advocating for better patient care ………..
Early Career Investigator
Dr. Elena Netchiporouk obtained her medical degree from the Université de Montréal in 2012 and her Royal College of Physicians and Surgeons of Canada certified training in dermatology from McGill University in 2017. During her dermatology residency, she also completed a 3-year Master’s program in Experimental Medicine at McGill University. As a clinician scientist, she focuses her research on understanding the interaction between environment and ….
Catalyzing Multicentre Skin ResearchSkIN Canada is developing a consortium of research sites that will collectively drive the formation of new multi-centre research projects. Research sites in the federation will have access to a suite of resources that will make it significantly easier to implement skin research.
Training and Education Initiatives
Inspiring the future of skin research with talent development & education. The COVID-19 pandemic has reinvented the way we exchange knowledge, offering unique and equitable opportunities to connect virtually and educate skin researchers and patients across Canada. LEARN MORE
Canadian Network of Skin Trials (C-NeST) – Pilot Projects
To help establish a framework for coordinating multi-centre skin studies involving community and academic research sites, the clinical trials arm of SkIN Canada initiated two pilot non-interventional research projects.
The CAPP – CIHR-IMHA Studentships in Psoriatic Disease provide undergraduate and health professional students with opportunities to undertake research projects related to psoriatic diseases with established investigators in an environment that provides strong mentorship. We encourage applications from across Canada by April 11, 2022. The Canadian Association of Psoriasis Patients (CAPP) was formed in 2012 to serve people impacted by psoriasis and psoriatic arthritis. CAPP’s mission is to be a resource to these people by improving their quality of life, raising awareness, providing education, advocating for better access to care and treatments, and supporting research.
The Institute of Musculoskeletal Health and Arthritis (IMHA) funds health research in order to develop and support a well-trained base of investigators with the skills and expertise needed to design and conduct innovative and diverse research and knowledge translation activities aimed at improving health.
If you are a healthcare provider, we would like to hear your perspectives on medication use during infant feeding.
Patient research partners have recently written about tokenism in research partnerships with patients
– and most importantly, what can be done to address it. Learn more about how to meaningfully include patients and patient organizations as research partners.
The program will provide $20,000 of support to as many as eight trainees or students to conduct one year of mentored research in the field of pediatric dermatology. Applications are due March 31, 2022 for fellowships beginning on July 1, 2022. For additional information, including eligibility criteria and instructions on how to apply, please see the Research Fellowship RFA.