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Building trial capacity in systemic sclerosis: setting the stage for cohort-embedded pragmatic clinical trials

Université de Montréal
8 Sites
ON, QC, AB, BC, MB

Dr. Sabrina Hoa

When the skin is injured, it usually heals smoothly, but sometimes scars form that are thick, raised, painful, or restrict movement. These are called problematic scars. The goal of this project is to understand why some people develop these abnormal scars by studying the immune and healing cells in the skin. We will create a national research network linking doctors and scientists who study wound healing and scarring, and collect small skin samples from people with different types of scars and from those living with systemic sclerosis (a disease that causes severe skin and organ fibrosis). By comparing normal and scarred skin using advanced genetic tools, we aim to find the immune pathways that lead to scarring. This information will help identify new ways to prevent or treat problematic scars. The project will also involve patients in designing research that reflects their lived experience and priorities. In the long term, this collaboration will lead to new treatments to reduce scarring and improve the lives of Canadians affected by these conditions.

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Can‑PG: A Canadian Network for Pyoderma Gangrenosum Patients and Outcomes

Women’s College Hospital - University of Toronto
6 Sites
ON, QC, AB, BC, NL
Dr. Mélanie Laurin, PhD

Optimization of a mouse xenograph platform to study BCC progression

Centre de recherche du CHU de Québec – Université Laval
2 Sites
QC

Immune-Mediated Pathways of Aberrant Scarring: Establishing a Canadian Collaborative Platformfor Translational Skin Research to Develop an Atlas of Skin Fibrosis

University of Calgary
3 Sites
AB, QC

Chemoprevention of cutaneous squamous cell carcinoma using topical 5-fluorouracil based therapies in solid organ transplant recipients: multicentre, pragmatic, parallel three group randomized trial

Women’s College Hospital
Dr. Rachel Asiniwasis MD MS(HS) FRCPC FAAD

East-West national Indigenous atopic dermatitis community and research collaborative core seed working group

First Nations University of Canada
4 Sites
SK, QC, MB
Dr. David Croitoru, MD

Surgical management of hidradenitis suppurativa with deroofing vs wide local excision: a multi-centre retrospective cohort study

University of Toronto, Women’s College Hospital
4 Sites
ON, QC, BC, AL

Canadian Frostbite Collaborative Network Symposium and Research Planning

NOSM University
2 Sites
YK, MB
Dr. Aaron Drucker, MD, SCM, FRCPC

Online clinical trials infrastructure to study low-risk interventions for atopic dermatitis

Women’s College Hospital
4 Sites
QC, AL, ON, UK

Establishing a National Registry and Biobank for Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)

McGill University Health Centre
5 Sites
QC, ON, BC
Marlene Dytoc

The Development of a Psychodermatology Risk Assessment Tool: Improving Care for Patients with Atopic Dermatitis and Other Psychodermatologic Conditions

The University of Alberta, Kaye Edmonton Clinic
2 Sites
AL, QC
Dr. Sarvesh Logsetty, MD, FRCS(C) FACS

Development of multicentre Burn Platform adaptive Trials team

The University of Manitoba
8 Sites
WPG, QC, ON, BC, AL

Using pathology reports to enable population-based studies of rare skin disease

Women’s College Hospital
4 Sites
ON, BC, AL, QC, NS

Canadian Transplant Dermatology Research Network

Women’s College Hospital
4 Sites
ON, BC, AL, QC, NS
dr.sarah detrich

Development of a multi-center research team to explore the potential of anti-mesothelin 1 gene therapies for fibrotic scleroderma

The University of British Columbia
3 Sites
BC, AL, QC
Brett Thombs

A New Patient-Researcher Partnership for Research on Itch inSystemic Sclerosis

Lady Davis Institute for Medical Research
6 Sites
ON, QC
Mina Tadrous

Evidence-based Management of Skin conditions Collaborative (EMSC)

Leslie Dan Faculty of Pharmacy, University of Toronto
5 Sites
ON
Maryam Piram

Autoinflammatory Skin Diseases – Creation of a Canadian Network (skinSAIDcanada)

Université de Montreal
4 Sites
ON, BC, AL, QC

Canadian Atopic dermatitis Cohort for Translational Immunology and imaging (CACTI) BRONTE trial (BROadband vs Narrowband phototherapy for eczema)

Women’s College Hospital
3 Sites
ON, QC, BC

Canadian Morphea Registry (C-MORE)

McGill University
15 Sites
BC, AB, SK, ON, QC, NS,NB

Follow-up of Cutaneous SCC (FOCS)

Women’s College Hospital
23 Sites
BC, AB, ON

Effect of allergy testing on atopic dermatitis in adults (EAT-AD)

Women’s College Hospital
8 Sites
BC, AB, ON, QC, NS

SPRINTR trial (Skin cancer Prevention with Nicotinamide in Transplant Recipients)

Women’s College Hospital
9 Sites
BC, AB, ON, QC

Establishing and optimizing skin cancer biobanking across Quebec

Lady Davis Institute
4 Sites
QC

Canadian Frostbite Collaborative: National website development

NOSM University
3 Sites
YT, MB, ON

A multi-province platform for Merkel cell carcinoma health services research

Queen’s University
3 Sites
ON, AB, BC, NS

Development of an in vivo mouse screening platform to identify molecular effectors of non-melanoma skin cancers

Université Laval
2 Sites
ON, QC

A Canadian interdisciplinary collaboration for patients with hidradenitis suppurativa

Sunnybrook Hospital
5 Sites
ON

A multicenter collaborative skin research group focusing on novel treatment for epidermolysis bullosa

Université Laval
3 Sites
ON, QC

Canadian Patient-Oriented Dermatitis database and biobank (C-POD)

McGill University
5 Sites
ON, QC, BC

Setting up the conditions for the biobanking of tissues and cells from hypertrophic scars

Université Laval
2 Sites
MB, QC

Hidradenitis Suppurativa in Diverse Patient Populations: Multicenter Pilot Project to Assess Disease Characteristics and Access to Biologic Therapy

Sunnybrook Research Institute
7 Sites
MB, QC, ON

Genodermatoses Network: A Canadian multidisciplinary collaboration for patients with genetic skin disorders

The Hospital for Sick Children +1
8 Sites
AB, QC, ON, BC
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Informing a Canadian Skin Science Trainee Program Based on the State of Trainee Programs Offered by International Academic Societies

Mapping skin research expertise across Canada

Priority Setting Initiative

Master Data Sharing Agreement
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Noninferiority Randomized Controlled Trials