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Chemoprevention of cutaneous squamous cell carcinoma using topical 5-fluorouracil based therapies in solid organ transplant recipients: multicentre, pragmatic, parallel three group randomized trial

Women’s College Hospital

Dr. An-Wen Chan

Inaugural Canada-UK clinical trial collaboration funded by CIHR

After two years of preparatory work, SkIN Canada and UKDCTN (UK Dermatology clinical trials network) are aiming to launch our first joint clinical trial next year involving 25 sites in Canada and the UK.

Supported by C-NeST (Canadian Network for Skin disease Trials) and led by Drs. An-Wen Chan, Aaron Drucker, and Joseph Kim (Canada), and Drs. Catherine Harwood, Rubeta Matin, and Charlotte Proby (UK), this pivotal multinational randomized trial was recently awarded peer-reviewed grant funding from CIHR ($1.4 million) and Cancer Research UK ($3.4 million).

The trial will evaluate the benefits and harms of 5-fluorouracil cream alone and combined with calcipotriol for preventing cutaneous squamous cell carcinoma in high-risk kidney, liver, lung, and heart transplant recipients

Canadian co-investigators: Sheila Au, Jennifer Beecker, John Gill, Sita Gourishankar, Glen Hazlewood, Sandra Holdsworth,  Sunil Kalia, Greg Knoll, Ngan Lam, Régine Mydlarski, Barry Shaw, Aman Sidhu, Muba Taher, George Tomlinson

view our other projects

Dr. Rachel Asiniwasis MD MS(HS) FRCPC FAAD

East-West national Indigenous atopic dermatitis community and research collaborative core seed working group

First Nations University of Canada
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Dr. David Croitoru, MD

Surgical management of hidradenitis suppurativa with deroofing vs wide local excision: a multi-centre retrospective cohort study

University of Toronto, Women’s College Hospital
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ON, QC, BC, AL

Canadian Frostbite Collaborative Network Symposium and Research Planning

NOSM University
2 Sites
YK, MB
Dr. Aaron Drucker, MD, SCM, FRCPC

Online clinical trials infrastructure to study low-risk interventions for atopic dermatitis

Women’s College Hospital
4 Sites
QC, AL, ON, UK

Establishing a National Registry and Biobank for Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)

McGill University Health Centre
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QC, ON, BC
Marlene Dytoc

The Development of a Psychodermatology Risk Assessment Tool: Improving Care for Patients with Atopic Dermatitis and Other Psychodermatologic Conditions

The University of Alberta, Kaye Edmonton Clinic
2 Sites
AL, QC

Dr. An-Wen Chan, MD, DPhil (Oxon) FRCPC, Dr. Anie Philip, PhD
Dr. Sarvesh Logsetty, MD, FRCS(C) FACS

Development of multicentre Burn Platform adaptive Trials team

The University of Manitoba
8 Sites
WPG, QC, ON, BC, AL

Using pathology reports to enable population-based studies of rare skin disease

Women’s College Hospital
4 Sites
ON, BC, AL, QC, NS

Canadian Transplant Dermatology Research Network

Women’s College Hospital
4 Sites
ON, BC, AL, QC, NS
dr.sarah detrich

Development of a multi-center research team to explore the potential of anti-mesothelin 1 gene therapies for fibrotic scleroderma

The University of British Columbia
3 Sites
BC, AL, QC
Brett Thombs

A New Patient-Researcher Partnership for Research on Itch inSystemic Sclerosis

Lady Davis Institute for Medical Research
6 Sites
ON, QC
Mina Tadrous

Evidence-based Management of Skin conditions Collaborative (EMSC)

Leslie Dan Faculty of Pharmacy, University of Toronto
5 Sites
ON
Maryam Piram

Autoinflammatory Skin Diseases – Creation of a Canadian Network (skinSAIDcanada)

Université de Montreal
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ON, BC, AL, QC

Canadian Atopic dermatitis Cohort for Translational Immunology and imaging (CACTI) BRONTE trial (BROadband vs Narrowband phototherapy for eczema)

Women’s College Hospital
3 Sites
ON, QC, BC

Canadian Morphea Registry (C-MORE)

McGill University
15 Sites
BC, AB, SK, ON, QC, NS,NB

Follow-up of Cutaneous SCC (FOCS)

Women’s College Hospital
23 Sites
BC, AB, ON

Effect of allergy testing on atopic dermatitis in adults (EAT-AD)

Women’s College Hospital
8 Sites
BC, AB, ON, QC, NS

SPRINTR trial (Skin cancer Prevention with Nicotinamide in Transplant Recipients)

Women’s College Hospital
9 Sites
BC, AB, ON, QC

Establishing and optimizing skin cancer biobanking across Quebec

Lady Davis Institute
4 Sites
QC

Canadian Frostbite Collaborative: National website development

NOSM University
3 Sites
YT, MB, ON

A multi-province platform for Merkel cell carcinoma health services research

Queen’s University
3 Sites
ON, AB, BC, NS

Development of an in vivo mouse screening platform to identify molecular effectors of non-melanoma skin cancers

Université Laval
2 Sites
ON, QC

A Canadian interdisciplinary collaboration for patients with hidradenitis suppurativa

Sunnybrook Hospital
5 Sites
ON

A multicenter collaborative skin research group focusing on novel treatment for epidermolysis bullosa

Université Laval
3 Sites
ON, QC

Canadian Patient-Oriented Dermatitis database and biobank (C-POD)

McGill University
5 Sites
ON, QC, BC

Setting up the conditions for the biobanking of tissues and cells from hypertrophic scars

Université Laval
2 Sites
MB, QC

Hidradenitis Suppurativa in Diverse Patient Populations: Multicenter Pilot Project to Assess Disease Characteristics and Access to Biologic Therapy

Sunnybrook Research Institute
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MB, QC, ON

Genodermatoses Network: A Canadian multidisciplinary collaboration for patients with genetic skin disorders

The Hospital for Sick Children +1
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AB, QC, ON, BC
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Informing a Canadian Skin Science Trainee Program Based on the State of Trainee Programs Offered by International Academic Societies

Mapping skin research expertise across Canada

Priority Setting Initiative

Master Data Sharing Agreement
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Noninferiority Randomized Controlled Trials